Bisabolol, also known as levomenol, is a monocyclic sesquiterpenoid alcohol. It is found in numerous varieties of cannabis, chamomile, and the South African candela tree. Bisabolol is recognizable for its sweet and light floral aroma.
Bisabolol has been used in the production of cosmetics, perfumery, and skincare products for hundreds of years. This is likely both due to its calming properties and subtle, pleasing aroma.
Bisabolol has been researched for its anti-inflammatory,1 anti-microbial,2 and analgesic properties.3 Bisabolol also has been studied for its ability to inhibit the growth of cancer cells.4 This research5 shows great promise for the treatment of multiple forms of cancer, along with the pain associated with current leading treatments, like chemotherapy.6
Cannabis strains that contain bisabolol include AC/DC, Pink Kush, OG Shark, Oracle, Headband, and Harle-Tsu.
Bisabolol has many biological and pharmacological properties. It has been researched for its many therapeutic effects, including antioxidant activity, cytotoxic activity, neuroprotective effects, antimicrobial activities, and more. In one study, topical application of a spray containing ozonated sunflower oil and bisabolol resulted in complete healing of venous leg ulcers. There is additional evidence from an earlier study that it's also helpful as a topical for easing atopic dermatitis. In a hamster model, bisabolol was successful in suppressing Leishmania. In addition to in vivo wound-healing activity, oral administration of bisabolol in a docking study revealed it to effectively reduce the parasitic load in mice's spleen and liver with no significant adverse effects on mammalian cells. Bisabolol's resistance toward certain fungal species can make it a good candidate for protecting immunosuppressed persons from fungal infections. The antifungal activity can prevent fungal growth and prevent the patient from becoming more vulnerable to infectious diseases. Its anticancer actions are what make bisabolol so interesting to medical researchers. It's been heavily studied in relation to liver cancer and non-small cell lung cancer. Its inhibitory activity toward the growth of cancerous cells and ability to fast-track apoptotic cells toward becoming dead cells make it a potential source of aid in developing anticancer drugs. There are many more researched biological activities and substantial evidence that bisabolol has a cytotoxic effect on human and rat glioma cells. Bisabolol can also protect HK2 cells against repercussions from acute kidney injury. Derivatives of the terpene can inhibit the growth of pancreatic cancer cells and protect neuro-2a cells.
Lab Effects is a trusted source for all terpene categories (CDTs, BDTs, flavors, therapeutics, water-soluble, flowable powders, etc.) and is available in every format suitable for various manufacturing processes. Bisabolol has shown much therapeutic potential for medical applications in experimental studies. Isolated terpenes purchased from Lab Effects are guaranteed pure, 100% botanically derived, and free from chemical adulterants such as synthetic flavorants, industrial odorizers, solvents, pesticides, and metals.
Bisabolol is used heavily in the cosmetics industry and also pharmaceutical products, particularly those intended for wound healing, skin irritation, and more. The terpene's ability to reduce oxidative stress via radical scavenging makes it particularly useful for skin care. The ability to mitigate oxidative stress goes beyond skin care. In a study of ischemic injury in mice receiving bisabolol in oral administration, there was a significant reduction in neuronal degeneration and improvement in locomotor activity thanks to reduced oxidative stress.
Bisabolol is a monocyclic sesquiterpene alcohol that was first identified and extracted from the chamomile plant but is also present in other botanicals, like the bark of the Brazilian candeia tree (Eremanthus erythropappus) and cannabis plants.
Like all terpenes, bisabolol can be extracted from plants and is thus a natural ingredient. Some terpenes can also be created synthetically, and these compounds are identical to extracted terpenes, but not all people consider them "natural." Lab Effects uses only natural cannabis and botanicals for terpene extraction.
Bisabolol does have an anti-nociceptive effect, blocking sensations of pain. For chronic pain patients, perceived cessation of pain can lead to feelings of euphoria and relaxation.
Bisabolol is also known to have anti-inflammatory effects. It is used in commercial products—typically ointments and creams, although also as a mouthwash—to encourage wound healing. The terpene may also have anti-inflammatory effects and other implications for patients with Alzheimer's and other neurodegenerative diseases thought to be connected to inflammation. Bisabolol has neuroprotective properties and may be able to play a neuroprotective role in Alzheimer's treatment, reducing anxiety and improving memory.
1. https://www.ncbi.nlm.nih.gov/pubmed/24894548
2. https://www.ncbi.nlm.nih.gov/pubmed/22939370
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751100/
4. https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-45
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/
6. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/chamomile