Isopulegol, notable for its potent minty aroma, is found in the essential oils of a variety of plants including lemongrass, lemon balm, geranium, and eucalyptus. Menthofuran (as it is found in the peppermint plant) and the sweetener hernandulcin (which is found mainly in the plant Lippia dulcis) can also be produced from isopulegol.
Isopulegol is a chemical precursor for menthol and is produced by freezing peppermint oil. This process1 is used commercially to supplement the natural sources of menthol. Because of its cooling, minty properties, isopulegol is a common additive in cosmetics, soaps, and other scented personal care products. Isopulegol is also used in medicinal preparations.
Further studies are necessary to discover the extent of isopulegol’s health benefits, but research has shown promising links between isopulegol and anti-inflammatory, anti-seizure, anti-inflammatory, antiviral, and gastroprotective2 effects.
Lemon balm, of which isopulegol is a significant component, contains notable inflammation-fighting properties.3 The antiviral properties of isopulegol could be highly effective against the H1N1 and H1N2 strains of the influenza virus, especially during the virus’s early stages.4 Isopulegol’s ability to affect the GABA system and its antioxidants is linked to a reduction in seizures.5
The Kosher Tangie strain of cannabis has higher-than-average levels of isopulegol.
Isopulegol is a terpene with many beneficial properties if handled correctly. It's common as part of an array of aroma or fragrance ingredients in various cosmetics and has a pleasant minty odor.
Unlike many terpenes, which contain odor agents specifically designed to ward off predatory insects or animals that would eat them, isopulegol has phagostimulatory activity, meaning it can encourage or stimulate feeding. This is beneficial for plants that depend on birds, insects, or small mammals to distribute seeds through feeding and excretion.
However, isopulegol also commands a deterrent activity and can be a hazard if handled improperly in purified form (like many raw materials). It can cause skin and/or eye irritation, and in cases of such raw ingredients and contact with skin or contact with eyes, medical advice should be sought promptly.
Lab Effects is a trusted source for all categories of terpenes (CDTs, BDTs, flavors, therapeutics, water-soluble, flowable powders, etc.) available in every format suitable for various manufacturing processes. Isopulegol has shown much therapeutic potential for medical applications in experimental studies. Isolated terpenes purchased from Lab Effects are guaranteed pure, 100% botanically derived, and free from chemical adulterants such as synthetic flavorants, industrial odorizers, solvents, pesticides, and metals.
Currently, isopulegol is used commercially in the soap and cosmetics industry. However, it also has promise in the pharmaceutical world. Preclinical animal tests showed that the terpene has the capacity for pain relief and could be a potential option for the development of treatments as alternatives to traditional pain medications.
Isopulegol may also be used as a gastrointestinal protectant, helping to prevent the formation of ulcers in one animal study. There is a wide range of applications for isopulegol when it comes to human health and entire fields of development for potential new and innovative medications for various ailments.
Isopulegol can be found in cannabis sativa, mint, citrus, and other common plants. It can also be derived from citronellol, thanks to citronellol's chemical structure and thermal cyclization.